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Continuous use of such drugs robs them of their energy to induce euphoria. Addictive substances maintain the brain so awash in dopamine that it eventually adapts by generating less of the molecule and becoming much less responsive to its effects. As a consequence, addicts develop up a tolerance to a drug, needing larger and larger amounts to get higher. In extreme addiction, people today also go through withdrawal—they feel physically ill, can not sleep and shake uncontrollably—if their brain is deprived of a dopamine-stimulating substance for also extended. At the very same time, neural pathways connecting the reward circuit to the prefrontal cortex weaken.
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